研究员，博士生导师。

云南生物资源保护与利用国家重点实验室

电话：0871-65033362

电子邮箱：liyan0910@ynu.edu.cn

教育背景：

2002.09-2008.07  中山大学                   本科、硕士

2008.09-2012.07  beat365官方网站                   博士

工作经历：

2012.07-2015.11  中国科学院昆明动物研究所   博士后

2015.12-今       beat365官方网站                   引进人才

2016.12-今       beat365官方网站                   研究员

2020.12-今       beat365官方网站                   博士生导师

主要研究方向

基于大规模组学数据，综合利用各种生物学方法，解析家养动物适应不同自然环境和社会环境的遗传机制；揭示家养动物的驯化起源历史及优质性状的遗传基础。

以第一作者及通讯作者身份发表SCI论文18篇（6篇影响因子大于15）。研究成果曾获得F1000推荐，MBE当期评注，以及国际知名媒体the New York Times、ScienceDaily及国内多家知名媒体报道。

入选人才项目

云南省中青年学术技术带头人后备人才

云南省万人计划青年拔尖人才

beat365官方网站青年英才培育计划

beat365官方网站东陆中青年骨干教师培育计划

主持的科研项目

1. 国家自然科学面上项目，2021.1-2024.12

2. 国家自然科学地区基金，2019.1-2022.12

3. 国家自然科学青年基金，2015.1-2017.12

4. 科技部国家重点研发计划子课题，2021.12-2026.11

4. 中科院先导项目子子课题，2018.3-2023.2

5. 科技部第二次青科考子课题，2019.11-2022.10

6. 云南省科技厅-beat365官方网站“双一流”建设“国家自然科学基金优秀青年培育”项目，2018.9.1-2020.8.31

7. beat365官方网站引智项目，2016.1-2023.12

第一及通讯作者论文（#共同第一；*共同通讯）

1. Yong Shao*,#, Xiao-Bo Wang*, Mei-Ling Zhang4 *, Yan Liu5 *, Sheng Wang, Bao-Lin Zhang, Min-Min Yang, Ming-Hai Yang, Ting Jia, Tian-Chun Pu, Yan  Lu, He Liu, Zhe Xu, Bo Li, Ning Liu, Violet Magoma Onsongo, Dong-Dong Wu, Cheng-Lin Zhang#, Jue Ruan#, Yan Li#. Long-read genome sequencing provides molecular insights into scavenging and societal complexity in spotted hyena Crocuta crocuta. Molecular Biology and Evolution, 2022, Jan 17;msac011. doi: 10.1093/molbev/msac011. Online ahead of print.

2.  Li Yan*, Wu Dong-Dong. Finding unknown species in the genomes of extant species. Journal of Genetics and Genomics. 2021, 48: 867-871.

3.  Nanaei Hojjat-Asadollahpour, Esmailizadeh Ali*, Mehrgardi Ahmad-Ayatollahi, Han Jianlin, Wu Dong-Dong, Li Yan*, Zhang Ya-Ping*. Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony. BMC Genomics. 2020, 21:496.

4. Wang Ming-Shan#, Wang Sheng#, Li Yan#, Jhala Yadvendradev#, Thakur Mukesh#, Otecko Newton O., Si Jing-Fang, Chen Hong-Man, Shapiro Beth*, Nielsen Rasmus*, Zhang Ya-Ping*, Wu Dong-Dong*. Ancient hybridization with an unknown population facilitated high altitude adaptation of canids. Molecular Biology and Evolution, 2020, 37(9):2616-2629 (Cover)

5. Li Ming-Li#, Tang Hui#, Shao Yong, Wang Ming-Shan, Xu Hai-Bo, Wang Sheng, Irwin David M., Adeola Adeniyi C., Zeng Tao, Chen Luonan#,*, Li Yan#,*, Wu Dong-Dong#,*. Evolution and transition of expression trajectory during human brain development. BMC Evolutionary Biology. 2020, 20:72.

6. Zhang Zhe, Khederzadeh Saber, Li Yan*. Deciphering the puzzles of dog domestication. Zoological Res. 2020, 41(2): 97-104.

7. Ma Xi-Yao#, Ning Tiao#, Adeola Adeniyi C.#, Li Jie#, Esmailizadeh Ali, Lichoti Jacqueline K., Agwanda Bernard R., Isakova Jainagul, Aldashev Almaz A., …& Li Yan*, Zhang Ya-Ping*. Potential dual expansion of domesticated donkeys revealed by worldwide analysis on mitochondrial sequences. Zoological Res. 2020, 41(1): 51-60.（Featured articles）

8. Li Y, Wang MS, Otecko NO, Wang Wen, Shi Peng, Wu DD, Zhang YP. Hypoxia potentially promotes Tibetan longevity. Cell Res. 2017, 27: 302-305

9. Li Y, Wang GD, Wang MS, Irwin DM, Wu DD, Zhang YP. Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis. Genome Biol Evol. 2014, 6(11):3115-3121

10. Li Y, Wu DD, Boyko AR, Wang GD, Wu SF, Irwin DM, Zhang YP. Population variation revealed high altitude adaptation of Tibetan Mastiffs. Mol Biol Evol. 2014, 31(5): 1200-1205

11. Li Y, vonHoldt BM, Wang GD, Reynolds A, Boyko AR, Wu DD, Zhang YP. Artificial selection on brain expressed genes during the domestication of dog. Mol Biol Evol. 2013, 30(8): 1867-1876

12. Li Y, Zhang YP. High genetic diversity of Tibetan Mastiffs revealed by mtDNA sequences. Chinese Sci Bull 2012, 57:1483-1487

13. Li Y, Zhang L, Zhang D, Zhang X, Lu X. Faster evolution of Z-linked duplicate genes in chicken. J Genet Genomics, 2010, 37(10):695-702

14. Adilijan Kader*, Li Y*, Kunzhe Dong, David M. Irwin, Qianjun Zhao, Xiaohong He, Jianfeng Liu, Yabin Pu, Neena A. Gorkhali, Xuexue Liu, Lin Jiang, Xiangchen Li, Weijun Guan, Yaping Zhang, Dong-Dong Wu, Yuehui Ma. Population variation reveals independent selection towards small body size in Chinese Debao pony. Genome Bio. Evol. 2015, 8(1):42-50

15. Wang MS*, Li Y*, Peng MS*, Zhong L, Wang ZJ, Li QY, Tu XL, Dong Y, Zhu CL, Wang L, Yang MM, Wu SF, Miao YW, Liu JP, Irwin DM, Wang W, Wu DD, Zhang YP. Genomic analyses reveal potential independent adaptation to high altitude in Tibetan chickens. Mol Biol Evol. 2015, 32 (7):1880-1889

16. Wu DD*, Ye LQ*, Li Y*, Sun YB, Shao Y, Chen CY, Zhu Z, Zhong L, Wang L, Irwin DM, Zhang YE, Zhang YP. Integrative analyses of RNA-editing, alternative splicing and expression of young genes in human brain transcriptome by deep RNA-sequencing. J Mol Cell Biol. 2015 7 (4):314-325

17. Liu HQ*, Li Y*, Irwin DM, Zhang YP, Wu DD. Integrative analysis of young genes, positively selected genes and IncRNAs in the development of Drosophila melanogaster. BMC Evol Biol. 2014, 14:241

18. Wu DD*, Wang X*, Li Y*, Zeng L, Irwin DM, Zhang YP. “Out of pollen” hypothesis for origin of new genes in flowering plants: study from Arabidopsis thaliana. Genome Biol Evol. 2014, 6(10):2822-9